Epidermal growth factor receptor

This article is about a cell surface receptor. For estimated measure of kidney function (eGFR), see Glomerular filtration rate.

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Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Cartoon diagram of the epidermal growth factor receptor (EGFR) (rainbow colored, N-terminus = blue, C-terminus = red) complexed with its ligand epidermal growth factor (magenta) based on the PDB 1NQL crystallographic coordinates.
Available structures: 1ivo, 1m14, 1m17, 1mox, 1nql,1xkk, 1yy9, 1z9i, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq,2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m
Identifiers
Symbols	EGFR; ERBB; ERBB1; mENA
External IDs	OMIM: 131550 MGI: 95294HomoloGene: 74545
EC number	2.7.10.1
[show]Gene ontology
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1956	13649
Ensembl	ENSG00000146648	ENSMUSG00000020122
Uniprot	P00533	Q3TQS6
Refseq	NM_005228(mRNA) NP_005219(protein)	NM_007912(mRNA) NP_031938(protein)
Location	Chr 7: 55.05 - 55.24 Mb	Chr 11: 16.65 - 16.81 Mb
Pubmedsearch	[1]	[2]

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands.^[1] The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4(ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.^[2]